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KMID : 0363219760140040357
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Korean Journal of Dermatology
1976 Volume.14 No. 4 p.357 ~ p.362
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A Study on Delayed Cutaneous Hypersensitivity Reaction to Various Skin Test Antigens in Patients with Leprosy
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孫淑子/Son, Sook Ja
方恩淑/金利中/金源錫/李昌雨/Bang, Eun Sook/Kim, E Joong/Kim, Won Suk/Lee, Chang Woo
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Abstract
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Several investigators have attempted to clarify the well-known phenomenon of anergy in lepromatous leprosy during past two decades, utilizing various methods-of immunologic assessment, including response to skin test antigens, active skin sensitization with strong allergens, skin homograft survival rate, immunopathology of lymphnodes, in vitro blastogenic response by antigens or mitogens of lymphocytes,. lymphokine production in vitro and measurement of peripheral T and B cell ratio.
However, there is no general agreement as to the cellular immunologic status of leprosy patients between various investigators. The present study was undertaken to evaluate the ability to mount cutaneous hypersensitivity reactions to various skin test antigens and to investigate active sensitization with DNCB in patients with leprosy.
Ten polar lepromatous (LL) and 12 polar tuberculoid (TT) patients who have been treated at Department of Dermatology, National Medical Center and Seoul National University Hospital were the subjects. The subjects have received regular antileprosy chemotherapy with DDS and the average duration of treatment in LL and TT groups was 6.2 and 4.7 years, respectively. The control group included 10 healthy physicians and nurses.
Skin test antigens included lepromin (1x10^(8) bacilli/ml), PPD (Parke-Davis, 5TU/0.lml), SK-SD (Lederle, 40 \bar(u) SK and 10 \baru SD/0.1 ml), Candidin (Hollister-Stier Lab., 1 : 1000 dilution) and DNCB aceton solution in the concentrations of 1000ug/ 0.lml for sensitization and 100ug/0.1m1 for challenge, respectively. Skin reactions were read 48 hours after intradermal injection of 0.1 ml of each antigen and the method of DNCB sensitization was same as described elsewhere.
The result showed that in polar lepromatous leprosy patients, the skin reactivity to various antigens were generally decreased, as compared to both the healthy control group and polar tuberculoid patients, especially to lepromin, PPD and DNCB sensitization (p <0.05, respectively).
We concluded that lepromatous leprosy patients were especially unresponsive to mycobacterial antigens (lepromin and PPD) and to newly administered antigen (DNCB) and the possible mechanism was discussed.
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KEYWORD
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